| Timothy Ley | |
|---|---|
| Institutions | The Genome Institute Washington University School of Medicine |
Timothy J Ley is an American hematologist, oncologist and cancer biologist. He is the Lewis T. and Rosalind B. Apple Professor of Oncology in the Department of Medicine, is chief of the Section of Stem Cell Biology in the Division of Oncology and is Professor of Genetics at Washington University in St. Louis. He is an associate director of The Genome Institute at Washington University. Dr. Ley's research group has focused on the reference sequence of the human genome to systematically identify the mutations responsible for the initiation and progression of acute myeloid leukemia (AML) and was part of the first group to fully sequence a cancer genome (of an AML patient).[1] To better understand the role of these mutations, he and his colleagues have constructed several mouse models of acute promyelocytic leukemia (APL), which are very similar to human APL.[2] Dr. Ley's laboratory has also defined the roles of granzymes for the functions of cytotoxic and regulatory T cells.[3]
Dr. Ley received his B.A. degree from Drake University in 1974, and his M.D. from Washington University School of Medicine in 1978. He did his internship and residency in Medicine at Massachusetts General Hospital, was a Clinical Associate at the NHLBI (National Heart, Lung, and Blood Institute), a Hematology-Oncology Fellow at Washington University Medical Center, and a Senior Investigator at the NHLBI before moving to Washington University in 1986.